| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 |
| filingDate |
1998-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32c2e54bf6a72e034121e2d1ac341040
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b46646039a32b75406225bd95abf37a |
| publicationDate |
2003-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003009009-A1 |
| titleOfInvention |
Modified cytokine receptor protein |
| abstract |
Disclosed as a modified extracellular domain of a cytokine receptor protein, capable of being crystallized without being complexed to a ligand molecule. The receptor preferably is a homo- or heterodimeric cytokine receptor, having at least one molecule segment which contributes to a disordered structure deleted. The most preferred receptor is human growth hormone receptor (hGHR). Also disclosed are crystals of unliganded modified receptor suitable for binding studies with ligand candidates a method of obtaining the crystals, as well as a method of designing drugs with cytokine receptor activity by employing such crystals according in binding studies with selected ligand candidates. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007031926-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006001770-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1544209-A1 |
| priorityDate |
1997-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |