http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003004330-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c999fee6428152a996011d506925c2d7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16 |
| filingDate | 2002-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c605301fca1ebb04a4f87aef9847a04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac94b91242afc33b64f216cf61fb8b51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_933be955bb24edc0d0df4da4e06d749e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5e7de00a8ba158563ef1cdcd7fe5c3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c7be7c4ff4df97e3e6f5cb4bb12df0c |
| publicationDate | 2003-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003004330-A1 |
| titleOfInvention | Methods for producing nucleoside derivatives and intermediates therefor |
| abstract | Novel intermediates of nucleoside derivatives, of which the 6-position of the nucleic acid base moiety is substituted with a halogen atom, are produced. Using those novel intermediates, even substrates, of which the 3′-position of the saccharide moiety is deoxylated, can be substituted at the 2′-position at an extremely high yield. Specifically, by subjecting a 3′-deoxy derivative of inosine to 6-halogenation to give a 6-halide of the derivative, and then subjecting it to 2′-deoxylation/substitution with a fluorine atom or the like, followed by further subjecting it to substitution with an amino group, a hydroxyl group or any other intended substituent at the 6-positioned halogen atom, nucleoside derivatives are produced at a high yield. n Methods for producing nucleoside derivatives including 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA) and their related compounds, in a simplified manner, at a high yield and at low costs, and especially Economical methods for substituting substrates, of which the 3′-position of the saccharide moiety is deoxylated, at the 2′-position to produce those nucleoside derivatives on an industrial scale are also provided. |
| priorityDate | 1998-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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