| abstract |
Disubstituted bicyclic heterocycles of general formula I n Ra—A-Het-B—Ar—E (I). n Compounds of general formula I, wherein E is an R b NH—C(=NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E is a cyano group, are valuable intermediates for preparing the other compounds of general formula I. |