| abstract |
The present invention relates to novel fatty acid analogues of the general formula (I): CH 3 —[CH 2 ] m —[x i —CH 2 ] n —COOR, wherein n is an integer from 1 to 12, and wherein m is an integer from 0 to 23, and wherein i is an odd number which indicates the position relative to COOR, and wherein X i independent of each other are selected from the group comprising O, S, SO, SO 2 , Se and CH 2 , and wherein R represents hydrogen or C 1 -C 4 alkl, with the proviso that at least one of the X i is not CH 2 , or a salt, prodrug or complex thereof, for the preparation of a pharmaceutical composition for the treatment and/or prevention of primary and/or secondary stenosis. Further the present invention relates to the use of said compounds for the prevention and/or treatment of a disease caused by procedural vascular trauma and/or pathological proliferation of smooth muscle cells, and/or an increased level of plasma homocysteine. |