| abstract |
The present invention relates to 16-membered macrocyclic compounds. In one aspect of the present invention, compounds of the formula n n n are provided wherein: n R 1 , R 2 , R 3 , and R 5 are each independently hydrogen, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl or alkylaryl; n R 4 is hydrogen, halogen, C 1 -C 10 alkyl, C 1 -C 10 hydroxyalkyl, C 1 -C 10 haloalkyl, aryl, —C(═O)R 6 , —C(═O)OR 6 , —NR 6 R 7 where R 6 and R 7 are each independently hydrogen, C 1 -C 10 aliphatic, aryl or alkylaryl; n W is O, NR 8 where R 8 is hydrogen, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl or alkylaryl; n X is O, CH 2 or a carbon-carbon double bond; n Y is absent or a C 1 -C 10 alkyl, C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl; and n Ar is aryl; provided that 10,11-dehydroepothilone C is excluded. |