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filingDate 2002-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcc166960aa63c5c1184aea7c5ef470b
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publicationDate 2002-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2002192690-A1
titleOfInvention Epitope-captured antibody display
abstract Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is expressed from a heterologous nucleic acid borne by the package, and one or more antibodies complexed with the expressed protein and which have an open binding site for a target protein. Thus, a segment of the nucleic acid encodes for an epitope that is shared by the expressed polypeptide and the target protein. The reagents can be utilized individually or as part of a library or an array to bind target proteins within protein samples to form one or more complexes. By determining the sequence of the segment of the heterologous nucleic acid of a package within a complex, one can identify the target protein since the segment encodes for an epitope that is shared by the expressed and target proteins.
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011092384-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007190607-A1
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