| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5061 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2001-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30f4f8218b023024573678c92fb4c9bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2c8c1e6bd8e99a3e754ac236b99d3b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_360c0da966595e72d38db3fbae30dc99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85ca1fab0e79201b8313b32b53286259 |
| publicationDate |
2002-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2002188212-A1 |
| titleOfInvention |
High throughput biological heart rate monitor that is molecularly determined |
| abstract |
This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells, each 3 mm by 3 mm in inner diameter. Cardiac myocytes disaggregated from neonatal animals are plated onto the bottom of each well and grown under standard tissue culture conditions. The chamber holds from 24-96 such wells. When drugs are to be assayed, the cells in each well are loaded with a calcium sensitive dye and the beating rate in each is monitored with a photodiode. Drug is added in graded concentrations to each well, and equilibrated and effects on rate are observed. This construct permits use of a cell based bioassay for the study of drugs or agents that may alter cardiac rate. This invention can be used in high throughput screening of drugs to evaluate/predict their effects on cardiac rate and rhythm. Further provided for by this invention is a A vector which comprises a compound which encode an ion channel. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009175790-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007048284-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004254134-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008181871-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8003618-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004204376-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009304588-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6849611-B2 |
| priorityDate |
2001-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |