| abstract |
1-Hydroxy pregnacalciferol derivatives of formula (I) and their corresponding 5,6-trans isomers wherein R 1 is hydroxyl or lower alkoxy and R 2 is optionally hydroxylated or lower alkoxylated lower alkynyl and R 1 is C(R A ) (R B )CH 3 where R A is optionally hydroxylated or lower alkoxylated lower alkynyl and R B is hydroxyl or lower alkoxy or R A and R B together represent oxo and R 2 is hydrogen, hydroxyl or lower alkoxy, and R 3 and R 4 represent hydrogen atoms, exhibit anti-progesterone activity and may be useful as antineoplastic, antifertility, antiproliferative, immunosuppressive and/or antiinflammatory agents. |