| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b221fcdd3a0494acead4386b3be5b09 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C01F11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-401
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate |
2002-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_445489ce6cf1e1a132f017b781b6582c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08842e4862390ec75189e2ae14a92c60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e5c79826ab7e9a4ab87ecb3b5fae302
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f28345c05c1914e11d68a03f526b456f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20cf6b96a92c0be2c205c4abb00a47e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42d3618c8d4b04b1edf45aabe5660630 |
| publicationDate |
2002-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2002156293-A1 |
| titleOfInvention |
Process for the preparation of zofenopril calcium salt |
| abstract |
A process for the preparation of polymorph A of zofenopril calcium salt in substantially pure form, which comprises: 1) reaction of S(-)-3-benzoylthio-2-methylpropanoic acid chloride with cis-4-phenylthio-L-proline in water at pH ranging from 9.0 to 9.5 and recovery of zofenopril in the acidic form; b) salification of acid zofenopril with a potassium salt in alcoholic solution, and recovery of the resulting potassium salt; c) conversion of the potassium salt to the calcium salt by addition of zofenopril potassium salt aqueous solution to a CaCl 2 aqueous solution at a temperature of 70-90° C. with simultaneous seeding to promote the precipitation of polymorph A. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2389360-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011098334-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007003963-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8710241-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8853421-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9221754-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010084515-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8119662-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011118328-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2389360-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011028736-A1 |
| priorityDate |
1998-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |