| abstract |
The invention concerns a saturated or unsaturated abietane derivative of general formula (I) wherein: Z is selected among —COOR 5 , —CONR 1 R 2 , —COONR 3 R 4 , —COR 6 , —CON, —COOR 5 , —CHOHR 7 , —SR 8 , —OR 8 , —CN, —CNO, —CNS, —NCO, —NCS and —R 1 R 2 CR 9 ; wherein R 1 , R 2 , R 3 and R 4 represent a hydrogen atom, a C 1 -C 10 alkyl, a C 6 -C 20 aryl optionally substituted, a C 7 -C 10 alkene, a C 1 -C 10 alkyne, or an aminoacyl or peptidyl optionally substituted; or R 1 and R 2 or R 3 and R 4 together form a cycle or a heterocycle; R 5 represents a hydrogen, a C 1 -C 10 alkyl, a C 1 -C 10 alkene, a C 1 -C 10 alkyne, or an aryl optionally substituted into C 6 -C 20 ; R 6 represents a hydrogen, a halogen, a C 1 -C 10 alkyl, a C 1 -C 10 alkene, a C 1 -C 10 alkyne, or an aryl optionally substituted into C 6 -C 20 ; R 7 represents a hydrogen, a C 1 -C 10 alkyl, a C 1 -C 10 alkene, or a C 1 -C 10 alkyne; R 8 represents a hydrogen, a C 1 -C 10 alkyl, a C 1 -C 10 alkene, or a C 1 -C 10 alkyne; and R 9 is selected among —CN, —CNO, —CNS, —NCO and —NCS. The invention also concerns a derived conjugate and the use of the derivative and the conjugate in a diagnostic composition, a reagent and a device. |