http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002150884-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2469-20 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5767 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-563 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-558 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-576 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-563 |
| filingDate | 2001-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49c220560a8b5daf9dc02908cfa6bd8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cde08deb9c880d056db18ef00a8c23d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d394e3a458d9c31ac77246f6aec69865 |
| publicationDate | 2002-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002150884-A1 |
| titleOfInvention | Oral fluid rapid assay for hepatitis C virus (HCV) antibodies using non-antibody labeling of IgA molecules recognizing HCV peptide epitopes |
| abstract | A method and device to detect Hepatitis C (HCV) antibodies in oral fluid is provided. This method introduces a non-antibody detection molecule that labels all classes of patient antibodies in oral fluid, followed by the specific concentration of labeled anti-HCV antibodies by selective capture in a trapping zone consisting of peptide antigens derived from the HCV genome. Signal generated by the labeled antibodies present in the trapping zone is proportional to the number of anti-HCV antibodies bound to the antigens present in the trapping zone. Presence of signal derived from the capture of antibody/detection molecule complexes in the trapping zone is indicative of past exposure to HCV. n Previous attempts to utilize oral fluid to screen for HCV exposure have been largely unsuccessful, likely due to the vastly decreased levels of antibody present in the oral fluid compared to serum- or plasma as well as the inability to detect other classes of anti-HCV than IgG. A method capable of utilizing oral fluid as an alternative to serum or plasma provides many advantages over traditional blood-based analyses. Oral fluid collection is rapid and non-invasive and eliminates the risks of needle exposure. Oral fluid can be collected by non-medical personnel, relieving health care professionals of the time-consuming and economic burden of obtaining serum samples. Furthermore, oral fluid-based assays may prove to be the preferred method of testing for infants, young children and in developing nations, as well as for patient groups where blood collection is difficult, such as intravenous drug, users, that constitute a significant portion of total HCV cases. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8871155-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005119589-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005202568-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8071394-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7837939-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10788482-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004237674-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7114403-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005106753-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7544324-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014323347-A1 |
| priorityDate | 2000-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.