| abstract |
Methods of forming and using signaling complexes (“Signalplexes”) expressed in specific tissues and organs during particular stages of development to predicably guide cell division, cell migration, differentiation of cells and/or formation of tissue or organ primordia in vitro. n Signal-plexes induce stem cells to express the same tissue and organ phenotypes as those from which the Signal-plexes were derived. Each member of the family of Signal-plexes induces differentiation of phenotypes only of a specific tissue or organ. Endocrine and exocrine pancreas, liver, lung, kidney, heart, cartilage, vascular, tendon, ligament and bone cells are induced in stem cells by Signal-plexes derived from each of the foregoing tissues as shown by morphology, immunostaining, ELISA, and RT-PCR analysis. |