http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002143011-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2773a2aeb05b5eabdf9e74906a9c5076 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D411-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C1-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-753 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C291-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C17-263 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C1-32 |
| filingDate | 2001-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ae0ea1f1bd906531bd904ebd0203552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_390c0f22542f4665c7adb454c35819d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb9a80fe78a012263007b04bfdf4d894 |
| publicationDate | 2002-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002143011-A1 |
| titleOfInvention | Tri-substituted phenyl derivatives and processes for their preparation |
| abstract | Compounds of general formula (1) are described: n n n wherein n ═W— is (1) ═C(Y)— where Y is a halogen atom, or an alkyl or —XR a group where X is —O—, —S(O) m —[where m is zero or an integer of value 1 or 2], or —N(R b )—[where R b is a hydrogen atom or an optionally substituted alkyl group] and R a is a hydrogen atom or an optionally substituted alkyl group or, (2) ═N—; n L is (1) a —C(R)═C(R 1 )(R 2 ) or [—CH(R)] n CH(R 1 )(R 2 ) group; is (2) a —(X a ) n Alk′Ar′, or Alk′X a Ar′ group; or is (3) X a R 1 ; n Z is a group (A), (B), (C) or (D): n n n wherein n Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; n Z 1 is a group —NR 12 C(O)—[where R 12 is a hydrogen atom or an optionally substituted alkyl or (Alk) t Ar group], —C(O)NR 12 —, —NR 12 C(S)—, —C(S)NR 12 —, —C≡C—, —NR 12 SO 2 —, or —SO 2 NR 12 —; n Alk is an optionally substituted straight or branched alkyl chain optionally interrupted by an atom or group X; n t is zero or an integer of value 1, 2 or 3; n R 3 is a hydrogen or a fluorine atom or an optionally substituted straight or branched alkyl group or an OR 11 group [where R 11 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkoxyalkyl, alkanoyl, formyl, carboxamido or thiocarboxamido group]; n R 4 is a hydrogen atom or an optionally substituted alkyl, —CO 2 R 8 , —CSNR 9 R 10 , —CN, —CH 2 CN, or —(CH 2 ) t Ar group where t is zero or an integer of value 1, 2 or 3 and Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; provided that when L is a group of type (2) or (3) above then Z is a group of type (A) or type (B) in which R 4 is a —(CH 2 ) t Ar group; n R 5 is a group —(CH 2 ) t Ar; n R 6 is a hydrogen or a fluorine atom, or an optionally substituted alkyl or —CO 2 R 8 , —CONR 9 R 10 , —CSNR 9 R 10 , —CN or —CH 2 CN group; n R 7 is a hydrogen or a fluorine atom, an optionally substituted straight or branched alkyl group, or an OR c group where R c is a hydrogen atom or an optionally substituted alkyl or alkenyl group, alkoxyalkyl, alkanoyl, formyl, carboxamido or thiocarboxamido group; and the salts, solvates, hydrates, prodrugs and N-oxides thereof. n Compounds according to the invention are phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of disease such as asthma where unwanted inflammatory response or muscular spasm is present. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7119119-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7932366-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8048924-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8314214-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8754197-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7151095-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003191186-A1 |
| priorityDate | 1994-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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