http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002142093-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd93e6674d9d0634d613426a97d2b387 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2984 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J13-125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1694 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 |
| filingDate | 2000-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8230e212bfe9f9fd44f5bd6a1721de0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c7783b427ec99c141740bbedf1a6aa1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84eb3c7d3c8f5f50955dd7c1c678c262 |
| publicationDate | 2002-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002142093-A1 |
| titleOfInvention | Emulsion-based processes for making microparticles |
| abstract | Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, and a second solvent that is totally or partially immiscible with the first solvent; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0.1% and 25% by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step. The emulsification and solvent removal steps are preferably conducted in a continuous process. The brief extraction step prior to evaporation minimizes the loss of active agent from the microparticles, and reduces the required volume of extraction phase as compared to other extraction-based processes. Alternate emulsification methods and solvent removal methods, such as incremental extraction, cryogenic extraction, or membrane separation, also are provided, and can be used in various combinations to make microparticles. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9315556-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011262508-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011125093-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007501108-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10137089-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7906148-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005016513-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006177370-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3166598-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9750794-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011223200-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8691723-B2 |
| priorityDate | 1999-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 676.