Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0356 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate |
2001-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db537c2030843cc674ced4ccfcc4f743 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_642e920f7940166325504069cfc828be |
publicationDate |
2002-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2002133837-A1 |
titleOfInvention |
Transgenic animals at a nuclear hormone receptor locus |
abstract |
The present disclosure relates to an inbred non-human transgenic animal having a multimeric nuclear hormone receptor, comprising a thyroid hormone receptor subunit and a nuclear hormone receptor subunit, wherein either or both the thyroid hormone receptor subunit and a nuclear hormone receptor subunits are mutated such that expression of said multimeric nuclear hormone receptor results in a measurable phenotype. The disclosure also contemplates methods of making inbred non-human transgenic animals. Methods of using the disclosed inbred non-human transgenic animals as models for various diseases and for screening small molecules that are determined to be efficacious in the treatment of such diseases are also disclosed. |
priorityDate |
2001-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |