| abstract |
The invention provides the use of the saponin derivatives, which is of the general formula (I) or the pharmaceutically acceptable salts and esters thereof: n n n R 1 is hydrogen, C 1-8 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-8 alkylhydroxy; n R 2 is hydrogen, C 1-8 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, COOH, COOC 1-8 alkyl; n R 3 is C 1-8 alkylhydroxy, hydrogen, C 1-8 alkyl, C2-6 alkenyl or C 2-6 alkynyl; n R 4 is a sugar residue; and n m is 0, 1, 2 or 3; n and pharmaceutically acceptable carriers, as well as the use of such pharmaceutical composition in the inhibition of sialyltransferases. |