http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002115117-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-723 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-743 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 2001-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3157eb67e7173021c40f0f91e2f7c886 |
| publicationDate | 2002-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002115117-A1 |
| titleOfInvention | ERbeta-mediated gene expression |
| abstract | An in vitro screening method for identifying a compound that modulates ERβ-mediated cell growth inhibition is disclosed. The method includes: providing a mammalian test cell containing a functional ERβ protein; contacting the test cell with a candidate compound; and detecting an increase or decrease in the expression of an ERβ-regulated gene in the presence of the candidate compound. Compounds that modulate ERβ-mediated cell growth inhibition can promote or inhibit this process. In some embodiments, the test cell contains no detectable ERα protein. The ERβ-regulated gene can be, e.g., the genes encoding receptor-like tyrosine kinase (RYK), 5-hydroxytryptamine A1 receptor (E2c), BCL-2 related A1, embryonic growth/differentiation factor, IL-12, TL1309, or IFN-α/β receptor. |
| priorityDate | 2000-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1216.