http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002110891-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-20 |
| filingDate | 2001-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2b246e02e9b55a27ab40e3abef108e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d09166a94ade7fc1ff45f1eae0cee670 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b4dc4dccc7f5e7a42070f507467cdd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_411ab145d6a3b2e2c6874f94fc00cdaa |
| publicationDate | 2002-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002110891-A1 |
| titleOfInvention | Phospholipase A2 group preferentially expressed in TH2 cells |
| abstract | Isolated nucleic acid molecules encoding a novel phospholipase A 2 , GXII PLA 2 , that is preferentially expressed in Th2 cells, are disclosed. The invention further provides recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, antisense nucleic acid molecules, non-human transgenic animals carrying a GXII PLA 2 transgene and non-human transgenic animals deficient in GXII PLA 2 . The invention further provides isolated GXII PLA 2 proteins and peptides, GXII PLA 2 fusion proteins and anti-GXII PLA 2 antibodies. Methods of using the GXII PLA 2 compositions of the invention are also disclosed, including methods for detecting GXII PLA 2 protein or mRNA in a biological sample, methods of modulating GXII PLA 2 activity in a cell, and methods for identifying agents that modulate GXII PLA 2 activity. Methods of modulating Th2 cell differentiation or activity by modulating either GXII PLA 2 or GV PLA 2 , which is also preferentially expressed in T cells, are provided. Methods for modulating prostaglandin production in Th2 cells by modulating GXII PLA 2 activity or GV PLA 2 activity are also provided. |
| priorityDate | 2000-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 879.