http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002102245-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2001-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15cc4b540001c45baa07c1cfbe4567a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e1d859a849b1914105888e68e430351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7d77fe8001e6c446072d395357e3ef4 |
| publicationDate | 2002-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002102245-A1 |
| titleOfInvention | 14-3-3sigma arrests the cell cycle |
| abstract | Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a growth arrest, with cells blocked in both the G1 and G2 phases of the cell cycle. The G1 block has been shown to be due to the p53-mediated induction of the cyclin-dependent kinase inhibitor p21 WAF1/CIP1/SDI1 , but the basis for the G2 arrest is unknown. Through a quantitative analysis of gene expression patterns in CRC cell lines, we have discovered that 14-3-3σ is strongly induced by γ-irradiation and other DNA-damaging agents. The induction of 14-3-3σ is mediated by a p53-responsive element located 1.815 kb upstream of its transcription start site. Exogenous introduction of 14-3-3σ into cycling cells results in a G2 block similar to that observed following irradiation. These results document a molecular mechanism for G2/M control that is regulated in human cells by p53. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003186331-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7186502-B2 |
| priorityDate | 1997-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 384.