| abstract |
The present invention discloses a reshaped human antibody against human IL-8 comprising: n (A) L chains each comprising: n (1) a human L chain C region; and, n (2) an L chain V region comprising a human L chain FR, and an L chain CDR of mouse monoclonal antibody against human IL-8; and, n (B) H chains each comprising: n (1) a human H chain C region; and, n (2) an H chain V region comprising a human H chain FR, and an H chain CDR of mouse monoclonal antibody against human IL-8. n Since the majority of this reshaped human antibody originates in human antibody and the CDR has low antigenicity, the reshaped human antibody of the present invention has low antigenicity to humans, and can therefore be expected to be useful in medical treatment. |