| abstract |
A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: n n n to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. n Novel compounds of the formulas n n n are disclosed. n Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. n Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. |