| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634d7355c2673489b2f4f800541770bb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-206
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-203
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-002 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-191 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate |
2002-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dce7e9c9d96360dada651dc5aa64ab0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a30269e4fa30237c47b59c66969e6c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8af1a7bbd118598dde7582f8904fabe9 |
| publicationDate |
2002-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2002065243-A1 |
| titleOfInvention |
Methods to enhance and confine expression of genes |
| abstract |
The present invention provides a novel approach to gene therapy of restricted areas such as tumors. The methods introduced here comprise: (a) placing a gene of interest in a plasmid vector driven by a heat or light inducible promoter; (b) modifying this vector by including a tetracycline responsive fusion protein which acts as a transcriptional activator, thus permitting regulation of gene expression by varying the levels of drug and; (c) modifying this vector by including DNA sequences that reduce or eliminate expression of genes in normal bystander cells. Also provided are a set of vectors for both sustained and regulable expression. There is also presented novel vectors for the gene therapy treatment of local and metastatic breast, ovarian and prostate cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8538520-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7840263-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006111512-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7774057-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006015146-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010179609-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007190028-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7764995-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9031792-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007054871-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005192637-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8346356-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2566345-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8060219-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7729761-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010175141-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9388425-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005164210-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7981065-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007036771-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10106817-B2 |
| priorityDate |
1998-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |