http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002062492-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 2001-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18c0854fc16c2670fcff4cc32fd664a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6821a10fdb28930fbdc14a72aa21856b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_268fce792c5a69a65b631688e4d8092c |
| publicationDate | 2002-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002062492-A1 |
| titleOfInvention | Transgenic animals expressing human coagulation factor VIII and von willebrand factor |
| abstract | A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human Factor VIII protein and a signal peptide, where the cis-acting regulatory units are active in mammary gland cells and the signal peptide is active in directing newly expressed Factor VIII into the milk of the animal. The promoter may be a milk protein promoter such as for whey acidic protein, casein, lactalbumin, or beta-lactoglobulin promoter. The transgenic mammals are preferably farm animals, for example, cows, goats, sheep, rabbits and pigs. Concurrent expression of a gene for human von Willebrand's Factor into milk may be used to stabilize newly-secreted Factor VIII. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017044864-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9095564-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9878017-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8603979-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011112023-A1 |
| priorityDate | 1994-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.