| abstract |
Methods to elevate white blood cell counts in animal subjects using compounds of formula (1) are disclosed. These compounds have the formula n Z-linker-Z′ (1) n or pharmaceutically acceptable salt thereof n wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; n Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula n —N(R)—(CR 2 ) n —X n wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; n “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms; n in an amount effective to elevate said WBC count in said subject. |