http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002052521-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65846 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-065 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6584 |
| filingDate | 2001-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_482b6b10aae3d62730f60cc6632d82ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5550039f0ef68d3dc164f445d234dc91 |
| publicationDate | 2002-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002052521-A1 |
| titleOfInvention | Ifosfamide, analogues thereof and their preparation |
| abstract | The present invention pertains to a compound of formula (I) n n n wherein R 1 and R 2 are each (CH 2 ) m X, each X is Cl or Br and m is 2 or 3, in combination with less than 0.5% w/w of the corresponding compound wherein R 1 is (CH 2 ) m H. Such compounds can be prepared by (i) the reaction of a Bronsted acid or a Lewis acid with NaBH 4 in an organic solvent, and (ii) adding the resultant solution to a solution of a corresponding compound wherein one of R 1 and R 2 is CO(CH 2 ) n X and the other is CO(CH 2 ) n X or (CH 2 ) m X, wherein n=m−1. Such compounds can also be prepared, in optically-enriched form, starting from an optically-enriched trihaloiminophosphorane of the formula R*N=Phal 3 wherein NR* is a chiral moiety derivable from a chiral amine or chiral sulphonamide of the formula R*NH 2 , which can be cyclisable with HO(CH 2 ) 3 NHR. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101962391-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004098010-A1 |
| priorityDate | 1995-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 137.