| abstract |
Compounds of formula (I) or a salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO 2 R 2 or COR 2 wherein R 2 represents hydroxy, methoxy, amino, alkylamino or dialkylamino; m is zero or an integer 1 or 2; R 1 represents a group (CH 2 ) n CN, —CH═CHR 3 , (CH 2 )nNHCOCH 2 R 4 or O(CH 2 )pNR 5 R 6 ; R 3 represents cyano or the group COR 7 ; R 4 represents alkoxy or a group NHCOR 8 ; R 5 and R 6 each represent independently hydrogen or alkyl, or R 5 and R 6 together with the nitrogen atom to which they are attached represent a heterocyclic group, or R 5 is hydrogen and R 6 is the group COR 9 ; R 7 represents an alkoxy, amino or hydroxyl group; R 8 represents a hydrogen atom or optionally substituted alkyl, alkoxy, aryl or heterocyclic group; R 9 is the group R 8 or the group NR 10 R 11 wherein R 10 represents hydrogen or alkyl group; R 11 represents optionally substituted alkyl, aryl, heterocyclic or cycloalkyl group; n is zero or an integer from 1 to 4; p is an integer from 2 to 4, processes for their preparation and to their use in medicine. |