| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N2005-1098
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0085 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate |
2001-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09016bca9ce1fc8f05acf0ac4cfb2885 |
| publicationDate |
2002-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2002051751-A1 |
| titleOfInvention |
Pharmaceuticals and apparatus providing diagnosis and selective tissue necrosis |
| abstract |
Pharmaceuticals and Apparatus used in combination for diagnosis and tissue necrosis applicable to provide effective and selective therapy using the Mossbauer absorption phenomenon. Selected pharmaceutical compounds containing a radiation absorber isotope are administered to a tissue and excited by a radiation source which provides energy at the corresponding resonant Mossbauer absorption frequency of isotope containing pharmaceutical, where excitation effects nuclear transitions to cause highly selective energy absorption in the selected target tissue. For diagnostic purposes, de-excitation fluorescence of the isotope is monitored. For therapeutic purposes, the energy is converted to particle radiation by the isotope at the target tissue by internal conversion followed by an Auger electron cascade which results in radiolysis of DNA resulting in lethal double strand breaks in the DNA molecules of the target tissue. The tissue selectivity is achieved by providing a Mossbauer absorption frequency of the target tissue which differs from that of surrounding tissue. The difference in frequency is due to the properties of the pharmaceutical, and/or an imposition of external magnetic fields or narrow beam ultrasonic power at the site of the target tissue. The magnitude of radiation absorption at the resonant Mossbauer frequency for the target tissue is of the order of one million times the absorption of surrounding nontarget tissue, which has a different Mossbauer absorption frequency, thereby producing considerably reduced side effects in comparison to conventional chemotherapy or radiation therapy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3607884-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011288409-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8337433-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9402593-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008208294-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11324962-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9535016-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011040295-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004236267-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11529111-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8790381-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7354433-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020030627-A1 |
| priorityDate |
1985-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |