http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002045780-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-14 |
| filingDate | 2001-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_986e49325b3e1562de50b991da744fd7 |
| publicationDate | 2002-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002045780-A1 |
| titleOfInvention | Biologically active spermidine analogues, pharmaceutical compositions and methods of treatment |
| abstract | Polyamines having the formula: n n n or a salt thereof with a pharmaceutically acceptable acid wherein: R 1 -R 5 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl or hydrogen; at least one of R 1 and R 2 and at least one of R 4 and R 5 are not hydrogen, and any of the alkyl chains may optionally be interrupted by at least one etheric oxygen atom, excluding N 1 ,N 3 -diethylspermidine and N 1 ,N 3 -dipropylspermidine; and n A and B are bridging groups which effectively maintain the distance between the nitrogen atoms such that the polyamine: (i) is capable of uptake by a target cell upon administration of the polyamine to a human or non-human animal; and (ii) upon uptake by the target cell, competitively binds via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intracellular natural polyamines in the target cell. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005233943-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7186825-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113735716-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018004467-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005080144-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004133013-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004235962-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008194697-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7491849-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11234945-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007161692-A1 |
| priorityDate | 1997-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 531.