| abstract |
A pyrrolesulfonamide derivative having the following formula (I): n n n wherein the ring P represented by n n n is a pyrrole ring having the following structure: n n n wherein R represents alkyl, cycloalkyl, cycloalkylalkyl or aralkyl; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z 2 is not present and Z 1 represents H but, when the bond is absent, Z 1 represents H and Z 2 represents OH or Z 1 and Z 2 are combined together to represent O or a group NOR 1 , in which R 1 represents H, or alkyl, aralkyl or aryl; l stands for 0 or 1; A represents alkylene, alkenylene or alkynylene; and Y represents a group n n n in which W represents CH, C═ or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C═; B represents a specific divalent group; E 1 and E 2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group. The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is useful as a therapeutic for circulatory diseases such as ischemic heart diseases, cerebrovascular disturbances and peripheral circulatory disturbances. |