Predicate |
Object |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 |
filingDate |
2001-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa5e993ec5df3eff635719d76cefdc25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1eab5b9919c888c1403947d5fbcd5c1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51d3d0be9b97b92ddc816d287297b3d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5edd9cfd4a1df197273b07243deb5e91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b47828afb7907039447308a2ae30326 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1152fe6b3ab4ab142ed6bf5a51b1ffec |
publicationDate |
2002-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2002037887-A1 |
titleOfInvention |
Method for reducing intraocular pressure using indole derivatives |
abstract |
The present invention provides a method of reducing intraocular pressure by administering pharmaceutical compositions comprising indole derivatives. The pharmaceutical compositions useful in this invention comprise indole derivatives and melatonin analogs of Formulae I-IV. A preferred embodiment is a method of lowering intraocular pressure using 5-(methoxycarbonylamino)-N-acetyltryptamine (5-MCA-NAT), also known as GR 135531, which has a prolonged duration of action and greater efficacy in lowering intraocular pressure compared to melatonin. The present invention further provides a method of treating disorders associated with ocular hypertension, and a method of treating various forms of glaucoma; the method comprises administering an effective dose of a pharmacuetical composition comprising an indole derivative with or without agents commonly used to treat such disorders. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9849135-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9850262-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11242361-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2023040398-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113880749-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006504681-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9556166-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11077128-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10532996-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10351568-B2 |
priorityDate |
2000-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |