| abstract |
The present invention relates to a polypeptide having 25-hydroxyvitamin D 3 -1α-hydroxylase activity, being useful for the prevention, diagnosis and therapeutic treatment of adult diseases such as osteoporosis induced by the decrease of active type vitamin D 3 and catalyzing the final stage of vitamin D 3 activation; and the gene encoding the polypeptide. n In accordance with the present invention, the following can be provided; a polypeptide having 25-hydroxyvitamin D 3 -1α-hydroxylase activity, DNA encoding the polypeptide, a recombinant DNA prepared by inserting the DNA in a vector, a transformant carrying the recombinant DNA, a method for preparing 25-hydroxyvitamin D 3 -1α-hydroxylase by using the transformant, a method for preparing 1α, 25-dihydroxyvitamin D 3 comprising using the polypeptide having 25-hydroxyvitamin D 3 -1α-hydroxylase activity, and an antibody recognizing the polypeptide. |