http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002028805-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
filingDate | 2001-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8857f00ac01b2c1c1b41d6e3f8282de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bb0fe58c8719a31c5c6c5105e4a0dc9 |
publicationDate | 2002-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2002028805-A1 |
titleOfInvention | Methods of inhibiting uterotrophic effects of estrogenic agents |
abstract | This invention comprises methods and pharmaceutical compositions for minimizing in a mammal the uterotrophic effect of a therapeutic compound selected from the group of tamoxifen, droloxifene, raloxifene, idoxifene, centrochroman, levor, meloxifene, TAT-59, GW 5838, or LY-353381 (?), comprising administration of a compound of the formulae I or II: n n n wherein: R 1 is selected from H, OH or the C 1 -C 12 esters or C 1 -C 12 alkyl ethers thereof, or halogens; or C 1 -C 4 halogenated ethers including trifluoromethyl ether and trichloromethyl ether; R 2 , R 3 , R 4 , R 5 , and R 6 are H, OH or C 1 -C 12 esters or C 1 -C 12 alkyl ethers thereof, halogens, or C 1 -C 4 halogenated ethers, cyano, C 1 -C 6 alkyl, or trifluoromethyl, with the proviso that, when R 1 is H, R 2 is not OH; Y is the moiety: n n n R7 and R8 are alkyl or concatenated together to form an optionally substituted, nitrogen-containing ring; or a pharmaceutically acceptable salt thereof. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005080870-A1 |
priorityDate | 2000-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 551.