| abstract |
This invention comprises methods of treating bone disorders and lowering blood LDL levels comprising administration of a bisphosphonate, an estrogen and compound of the formulae I or II: n n n wherein Z is a moiety selected from the group of: n n n wherein: R 1 is selected from H, OH or the C 1 -C 12 esters or C 1 -C 12 alkyl ethers thereof, benzyloxy, or halogen; or C 1 -C 4 halogenated ethers including trifluoromethyl ether and trichloromethyl ether; R 2 , R 3 , R 4 , R 5 , and R 6 are H, OH or C 1 -C 12 esters or C 1 -C 12 alkyl ethers thereof, halogens, or C 1 -C 4 halogenated ethers, cyano, C 1 -C 6 alkyl, or trifluoromethyl, with the proviso that, when R 1 is H, R 2 is not OH; Y is the moiety: n n n R 7 and R 8 are alkyl or concatenated together to form an optionally substituted, nitrogen-containing ring; or a pharmaceutically acceptable salt thereof. |