| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate |
2001-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a25bbf4394ed81fc34ec690bd3ce67e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e72b64ea2de1a165c82bf25913d3f00 |
| publicationDate |
2002-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2002026945-A1 |
| titleOfInvention |
Enhancement of photodynamic therapy by anti-angiogenic treatment |
| abstract |
Photodynamic therapy mediated oxidative stress elicits both direct tumor cell damage as well as microvascular injury within exposed tumors. Reduction in vascular perfusion associated with PDT mediated microvascular injury produces tumor tissue hypoxia. In a transplantable BA mouse mammary carcinoma, Photofrin mediated PDT induced expression of the hypoxia inducible factor-1 alpha (HIF-1α) subunit of the heterodimeric HIF-1 transcription factor and also increased protein levels of the HIF-1 target gene, vascular endothelial growth factor, within treated tumors. Tumor bearing mice treated with combined anti-angiogenic therapy (IM862 or EMAP-II) and PDT had improved tumoricidal responses compared to individual treatments. PDT induced VEGF expression in tumors decreased when either IM862 or EMAP-II was included in the PDT treatment protocol. Combination procedures using anti-angiogenic treatments improves the therapeutic effectiveness of PDT. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9527858-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9518062-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009192209-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7498029-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10159688-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016038515-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006084951-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009102960-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8829020-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002197262-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010010482-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007020272-A1 |
| priorityDate |
2000-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |