| abstract |
The present invention provides novel macrolide compounds of the formulas n n n wherein: n R is hydroxyl or methoxy; n R 1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH 2 , OR 9 , n n n where R 9 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl or heteroaryl and R 10 and R 11 are each independently hydrogen, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, or aryl; n R 2 and R 3 are each independently selected from the group consisting of hydrogen, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl, alkylaryl, alkenylaryl, alkynylaryl or R 2 and R 3 together form a cycloalkyl or a cycloaryl moiety; n R 4 is hydrogen or methyl; n R 5 is hydrogen, hydroxyl, oxo, or together with R 6 and the carbons to which they are attached form a cyclic carbonate; n R 6 is hydrogen, hydroxyl, OR 12 where R 12 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, or together with R 5 and the carbons to which they are attached form a cyclic carbonate; n R 7 is methyl, C 3 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; n R 8 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; and, n x is a single or a double bond. |