| abstract |
Compounds, compositions containing compounds, methods of using compounds, and processes of making compounds, of formula I containing at least one ring nitrogen: n n n or a pharmaceutically acceptable base or acid addition salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein: n X is double-bonded oxygen or —OH; n when R 7 is present, it is hydrogen or lower alkyl; n Y represents the atoms necessary to form a fused mono-, bi- or tricyclic, carbocyclic or heterocyclic ring, wherein each individual ring has 5-6 ring member atoms; and n Z is (i) —CHR 2 CHR 3 — wherein R 2 and R 3 are independently hydrogen, alkyl, aryl, or aralkyl; n (ii) —R 6 C═CR 3 — wherein R 3 and R 6 are independently hydrogen, lower alkyl, aryl, aralkyl, halo, —NO 2 , —COOR 7 , or —NR 7 R 8 where R 8 is independently hydrogen or C 1 -C 9 alkyl, or R 6 and R 3 , taken together, form a fused aromatic ring, wherein each individual ring has 5-6 ring members; n (iii) —R 2 C═N—; n (iv) —CR2(OH)—NR—; or n (v) —C(O)—NR 7 —. |