Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C247-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-06 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-83 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C247-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 |
filingDate |
2001-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c930e28f7f6336c7cb5b1d5377e03a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_911598c468eee2e2a65c3a23ae329e45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe493ed37bf67bb38702cdb4e02d4b49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b280d089fcc8727092de174b7c7a66b |
publicationDate |
2002-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2002016355-A1 |
titleOfInvention |
Synthesis of clasto-lactacystin beta-lactone and analogs thereof |
abstract |
The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteosome inhibitors. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008161282-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113024572-A |
priorityDate |
1997-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |