| abstract |
Polypeptides including an amino acid sequence corresponding substantially to KKEKDIMKK are provided. The polypeptides directly bind to MPG/NG2 proteoglycan and, when used as a soluble peptide, can inhibit melanoma cell adhesion. Antibodies generated against the polypeptides can bind α4β integrin and are capable of inhibiting α4β integrin-mediated cell adhesion. Medical applications such as prosthetic devices, percutaneous devices, cell culture substrates, affinity purification devices and chemodiagnostic devices are also provided. |