| abstract |
The invention concerns combinations of alpha adrenergic agents such as brimonidine and its derivatives as represented by formula (I) below n n n wherein each Y is independently selected from the group consisting of N, N—CH3, O, S and C—R 1 ; R 1 is hydrogen, lower alkyl or oxo; R 2 , R 3 and R 4 are independently selected from the group consisting of hydrogen, halogen, lower alkyl and lower alkenyl; n is an integer from 1 to 3; and a broken line beside a solid line indicates either a single or a double bond with the proviso that when n=1, both bonds from Y to C—R1 cannot be double bonds, n and prostaglandins known in the art to cause lowering of intraocular pressure n which are useful in compositions, methods of treatment and articles of manufacture for the treatment of glaucoma and alleviation of elevated intraocular pressure and providing neuroprotection. |