| abstract |
Methods are provided for preventing a cellular immune response to a pre-selected antigen by ex vivo or in vivo methods whereby dendritic cell maturation is permitted to occur in the absence of effective CD4+ T cell help. Under these conditions, elimination of cytotoxic T cells is achieved. The methods may be used for the prophylaxis of an undesired immune response to an autoimmune disease antigen, a transplant antigen, or reducing an exaggerated immune response to a antigen. |