| abstract |
Compound having the structure n n n where anthracycline, N, R a , X, R b, n and m are as defined in the specification. The compound of the invention is activatable in vivo by esterases and spontaneous dehydration to form an aldehyde. The aldehyde may couple to nucleophiles of intracellular macromolecules. The compounds of the invention are cytotoxically effective in the inhibition of human myeloma cells. |