http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2001051828-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3691 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3683 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3604 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3608 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3654 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3662 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-36 |
| filingDate | 2001-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cd23dc36c6051a7715d8265066b9474 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e5ae98e1f871b692e1873dbfafa0d38 |
| publicationDate | 2001-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2001051828-A1 |
| titleOfInvention | Anterior cruciate ligament xenografts |
| abstract | The invention provides an article of manufacture comprising a substantially non-immunogenic ligament or tendon xenograft for implantation into humans. The invention further provides a method for preparing a ligament xenograft by removing at least a portion of a ligament from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally chemical crosslinking. In addition to or in lieu of the above treatments, the methods include a cellular disruption treatment and either digestion of the carbohydrate moieties of the xenograft with a glycosidase in a range of about 1 mU/ml to about 1000 U/ml or glycosidase digestion followed by treatment for sialylation. The invention also provides articles of manufacture produced by one or more of the above-identified methods of the invention. The invention further provides a ligament xenograft for implantation into a human including a portion of a ligament from a non-human animal, wherein the portion includes extracellular components and substantially only dead cells having substantially no surface α-galactosyl moieties and having sialic acid linked to at least a portion of surface carbohydrate moieties. Each of the xenografts of the invention is substantially non-immunogenic and has substantially the same mechanical properties as the respective native ligament. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8753406-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2433492-A1 |
| priorityDate | 1995-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 177.