Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 |
filingDate |
2001-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86ba99740845212044f743908099ca58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10a785dbf1dceb21c603bab8716d435c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03faf295eeb9e3fa96fe267146e64f5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_418adda9479748957b2f519e6417d591 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f0d7cbf5361e2ec0a5d15bba25d2646 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69c5254eab58d237d65e68ee48fae143 |
publicationDate |
2001-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2001039333-A1 |
titleOfInvention |
Method of preparing form II crystals of clarithromycin |
abstract |
High purity Form II crystals of clarithromycin can be easily prepared in a high yield by a process comprising the steps of: protecting the 9-oxime hydroxy group of erythromycin A 9-oxime or a salt thereof with a tropyl group and the 2′- and 4″-hydroxy groups with trimethylsilyl groups; reacting 2′,4″-O-bis(trimethylsilyl)erythromycin A 9-O-tropyloxime with a methylating agent; removing the protecting groups and the oxime group of 2′,4″-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-O-tropyloxime to obtain crude clarithromycin; treating the crude clarithromycin with methanesulfonic acid in a mixture of a water-miscible organic solvent and water to obtain crystalline clarithromycin mesylate trihydrate; and neutralizing the crystalline clarithromycin mesylate trihydrate with aqueous ammonia in a mixture of a water-miscible organic solvent and water. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005220871-A1 |
priorityDate |
2000-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |