| abstract |
The present invention provides a general method for identifying genes and producing immunological reagents which encode cell surface antigens of human origin. Specifically, this invention provides a method for preparing a hybridoma cell line which produces an antibody which specifically recognizes and binds to a cell surface antigen associated with a neoplastic, human cell. This invention also provides a method for preparing a monoclonal and a polyclonal antibody which specifically recognizes and binds to a cell surface antigen associated with a neoplastic, human cell. Using the antibodies produced, this invention further provides a method for diagnosing in a subject a neoplastic condition, a method for treating a neoplastic condition, and a method for imaging a neoplastic, human cell. This invention also provides a method for preparing DNA encoding a cell surface antigen associated with a neoplastic, human cell, DNA probes hybridized with the DNA prepared therein, as well as a method for diagnosing a neoplastic condition using the DNA probes. |