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publicationDate 2001-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2001014473-A1
titleOfInvention Method for producing cartilagetissue and implants for repairing encholndral and osteochondral defects as well as arrangement for carrying out the method
abstract Cartilage tissue and implants comprising tissue are produced in vitro starting from cells having the ability to form an extracellular cartilage matrix. Such cells are brought into a cell space ( 1 ) and are left in this cell space for producing an extracellular cartilage matrix. The cells are brought into the cell space to have a cell density of ca. 5×10 7 to 10 9 cells per cm 3 of cell space. The cell space ( 1 ) is at least partly separated from a culture medium space ( 2 ) surrounding the cell space by means of a semi-permeable wall ( 3 ) or by an open-pore wall acting as convection barrier. The open-pore wall can be designed as a plate ( 7 ) made of a bone substitute material and constituting the bottom of the cell space ( 1 ). The cells settle on such a plate ( 7 ) and the cartilage tissue growing in the cell space ( 1 ). The cells settle on such a plate ( 7 ) and the cartilage tissue growing in the cell space ( 1 ) grows into pores or surface roughness of the plate, whereby an implant forms which consists of a bone substitute plate ( 7 ) and a cartilage layer covering the plate and whereby the two implant parts are connected to each other in positively engaged manner by being grown together.
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