abstract |
Novel compounds of the formula n n n or a pharmaceutically acceptable salt or solvate thereof, wherein: n the dotted line represents an optional double bond; n X 1 is optionally substituted alkyl, cycloalkyl, aryl, heteroaryl or heterocycloalkyl; n x 2 is —CHO, —CN, optionally substituted amino, alkyl, or aryl; n or X 1 is optionally substituted benzofused heterocyclyl and X 2 is hydrogen; n or X 1 and X 2 together form an optionally benzofused spiro heterocyclyl group n R 1 , R 2 , R 3 and R 4 are independently H and alkyl, or (R 1 and R 4 ) or (R 2 and R 3 ) or (R 1 and R 3 ) or (R 2 and R 4 ) together can form an alkylene bridge of 1 to 3 carbon atoms; n Z 1 is optionally substituted alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, or —CO 2 (alkyl or substituted amino) or CN ; Z 2 is H or Z 1 ; Z 3 is H oralkyl; or Z 1 , Z 2 and Z 3 , together with the carbon to which they are attached, form bicyclic saturated or unsaturated rings; pharmaceutical compositions therefore, and the use of said compounds as nociceptin receptor inhibitors useful in the treatment of pain, anxiety, cough, asthma, depression and alcohol abuse are disclosed. |