| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4d6892208f2a1718a4ecc4ad11a1edf |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C401-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C401-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-59 |
| filingDate |
1998-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af924d678a9ef83d98e80554019a6b87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a54ddf2f508fe7f687a29340af582723 |
| publicationDate |
2001-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2001007907-A1 |
| titleOfInvention |
3-epi compounds of vitamin d3 and uses thereof |
| abstract |
Novel 3-epi vitamin D 3 compounds having the orientation of the substituent attached to the carbon at position 3 of the A-ring of vitamin D 3 inverted from a beta (β) to an alpha (α) configuration are described. These 3-epi vitamin D 3 compounds were first identified as metabolites produced via a novel tissue-specific metabolic pathway which catalyzes the 3-β-hydroxy epimerization of vitamin D 3 compounds. Isolated 3-epimer forms of vitamin D 3 compounds have been characterized and shown to have improved biological properties compared to their isomeric counterparts, such as reduced hypercalcemic activity and enhanced stability in vivo. The vitamin D 3 compounds of the present invention can be used as substitutes for natural and synthetic vitamin D 3 compounds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9188596-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8617898-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111763230-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10702574-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011183429-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014127825-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11116816-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10406202-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10420819-B2 |
| priorityDate |
1997-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |