| abstract |
Methods, kits, apparatus, and compositions for inhibiting cephalic inflammation, including meningeal inflammation and cerebral inflammation for example, in a human patient are provided. The methods comprise intranasally administering to the patient a pharmaceutical composition comprising a local anesthetic, and preferably a long-acting local anesthetic ingredient. A composition useful for practicing the methods of the invention is described which comprises at least one local anesthetic in a pharmaceutically acceptable carrier, wherein the composition is formulated for intranasal delivery. A kit comprising the composition and an intranasal applicator is also included in the invention. Apparatus for delivering or applying the compositions of the invention or for performing the methods of the invention are also described. |