| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56983
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2000-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf746908c7b4dec16c4292beb64b1bb7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40fbbdb613d7bbace3e5e8d34024c36d |
| publicationDate |
2001-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2001001061-A1 |
| titleOfInvention |
Assay for disease related conformation of a protein |
| abstract |
An assay method is disclosed which makes it possible to determine the presence of a diseased related conformation of a protein (e.g., PrP Sc or the β-sheet form of βA4) in a sample. A sample is divided into two portions and the first portion is cross-linked to a first solid support and then contacted with a labeled antibody which binds to a non-disease form of the protein with a higher degree of affinity (e.g., 4 to 30 fold higher) than to the disease form of the protein. The second portion is treated in a manner which causes any disease form of the protein to change conformation to a form with a higher binding affinity for the labeled antibody. The treated second portion is then bound to a second solid support and contacted with labeled antibody. The level of labeled antibody binding to a protein in the first and second portions is determined and the amounts measured in each are compared. The difference between the two measurements is an indication of whether the disease related conformation of the protein was present in the sample. The method can also determine the concentration of the disease related conformation and the particular strain present. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1700096-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009191571-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011081660-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006057671-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9638702-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010304999-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008131907-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005287661-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006263837-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005282172-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02097444-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008034016-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009130774-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8178344-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011189692-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2085404-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7939641-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2312312-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005033687-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006286672-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009061462-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006275910-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008171341-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7166471-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1700096-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7799556-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7691639-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8062895-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8372593-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003215880-A1 |
| priorityDate |
1997-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |