| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df809f80345d5a8e7cafd6fd1188a474 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-865
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P2203-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02E50-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01049
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y202-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y501-03001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y501-03022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-185
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-01009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-18 |
| filingDate |
2019-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2023-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e4fc604a391e86a9e0045e54bc7671c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b0fc0f4127ccb8b2b6096de42514a7d |
| publicationDate |
2023-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-11555210-B2 |
| titleOfInvention |
Microbe having increased tolerance to phenolic fermentation inhibitors |
| abstract |
Embodiments provide a modified microbe capable of growing in or fermenting a solution, or lignocellulosic hydrolysate, comprising ferulic acid and/or coniferyl aldehyde. The microbe has one or more modifications to provide: (a) a decrease in copy number or expression of a BNA7 gene; (b) an increase in copy number or expression of one or more pentose phosphate pathway genes; and/or (c) localization of one or more products of the pentose phosphate pathway genes to the mitochondria or endoplasmic reticulum. Also provided is a microbe having modified expression or copy number of BNA7 and/or one or more of the pentose phosphate pathway genes. The pentose phosphate pathway genes may in certain embodiments be selected from at least one of ZWF1, TKL1, RPE1 and GND1. Also provided is a method for fermenting a substrate comprising ferulic acid and/or coniferyl aldehyde to produce a fermentation product. |
| priorityDate |
2018-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |